The BEST Builds I Played in Hell Clock 2.0 Tier 16 and More
If you want a single, practical resource that turns hours of trial-and-error into a handful of reliable templates, this is it. This guide distills the best builds I played in Hell Clock 2.0 and tunes them specifically for Tier 16 content and Endless Nightmares. Expect clear relic targets, blessing priorities, playstyle coaching, and endgame tuning so you can speedfarm maps or shred bosses without guessing which stat to chase next.
This is not a theory-only writeup. These are builds I ran repeatedly, refined across dozens of runs, and pushed into late-game content. The emphasis is on scalability—how a build grows from campaign to Tier 16—and on practical decisions you can copy into your next run.
How Tier 16 reshapes priorities
Tier 16 is a different game than early acts. Enemies hit harder, resistances matter more, and the difference between a good relic and a great relic is multiplicative scaling. At this level you should stop chasing flat damage and start hunting for multiplicative modifiers: elemental damage multipliers, projectile count, crit damage, on-kill multipliers, and effects that change how a skill behaves.
Survivability is not optional. A build that kills fast but dies to a single telegraphed attack will cost you more time than a slightly slower but consistent setup. For Tier 16, prioritize:
Sustained damage scaling over burst that peters out.
Defensive redundancy: one active defensive cooldown plus passive mitigation.
Relic synergy that converts or amplifies a single damage axis.
When you plan a build, pick one axis—fire, plague, lightning, or minion scaling—and double down. Spreading across many axes dilutes your relic power and slows progression.
How I tested and selected these builds
I judged builds on four practical axes: clear speed, bossing reliability, survivability, and ease of scaling. Each build below passed repeated runs in both campaign and Endless Nightmares, and each one includes a clear list of core relics, blessing priorities, and endgame tuning so you can replicate the results.
I limited the use of bullet lists to keep the flow readable and focused. Expect dense, actionable paragraphs and a few compact tables for direct comparisons and stat snapshots.
Build 1 — Plague Split Shot: the speedfarm workhorse
Overview and why it works Plague Split Shot is the archetypal map-clear build. It converts a high base projectile count into persistent area denial through plague clouds. With the right relics, it becomes a spray-and-forget engine that clears rooms faster than most alternatives while still delivering respectable boss damage.
Core relic combos The build needs relics that increase projectile count, plague damage, and on-hit plague spread. A weapon with projectile count and plague damage is the fastest route to consistent clears. Add a relic that turns hits into lingering clouds and another that multiplies plague damage on afflicted targets.
Blessing path Early blessings should boost projectile amount and flat plague damage to accelerate clear speed. Mid-game, pivot to plague damage multipliers and crit damage. Endgame blessings should lock in projectile count and any on-kill plague explosions.
Playstyle and micro decisions Move constantly. The build rewards mobility because plague clouds do the cleanup. Use short cooldown crowd-control abilities to reset dangerous packs. Against bosses, burst to apply plague stacks, then kite while clouds chip away. If a boss has a vulnerability window, time your highest-damage cooldowns to overlap with it.
Endgame tuning Aim for a weapon with at least +2 projectile count and a plague multiplier on the main relic. If you can craft a relic that converts a portion of physical damage to plague, do it—multiplicative conversions are the fastest path to Tier 16 viability.
Build 2 — Ignite Matadeira: AoE annihilation and boss shred
Overview and why it works Ignite Matadeira is the go-to when you want raw AoE power. The build uses oil mechanics and ignite stacking to create massive damage-over-time fields. Matadeira functions like a meteor: it sets up huge burn windows that melt both packs and bosses when timed correctly.
Core relic combos You want a Matadeira relic that increases AoE and ignite damage, a bottle-of-oil relic that increases oil application or duration, and a fire-orb relic that shreds resistances. A weapon with fire damage and AoE completes the core.
Blessing path Start with fire damage and ignite damage blessings to accelerate early scaling. Mid-game, pick AoE and duration blessings. Endgame, lock in ignite multipliers and any crit damage that affects fire.
Playstyle and micro decisions This build is setup-heavy. Oil groups, then detonate with Matadeira. Mobility is secondary; positioning and timing are primary. Against bosses, bait attacks to create safe windows for Matadeira drops. Use movement cooldowns to avoid telegraphed mechanics rather than to chase damage.
Endgame tuning Prioritize relics that increase ignite stacks per second and that convert a portion of damage into ignite. If you can craft a relic that reduces boss resistance to fire on hit, it multiplies your Matadeira output dramatically.
Build 3 — Tupã’s Wrath Spark Auto-Aim: tanky, consistent, low-aim
Overview and why it works Tupã’s Wrath is an auto-aim spark that scales with lightning and physical modifiers. It’s ideal for players who prefer a set-and-forget damage source with strong defensive options. The build trades some raw clear speed for consistency and survivability.
Core relic combos A lightning-orb relic that increases lightning damage and a relic that converts a portion of physical damage to lightning are core. Add a relic that increases conviction pool or grants passive mitigation to survive burst windows.
Blessing path Early blessings should favor lightning damage and physical damage. Mid-game, pick conviction and health multipliers. Endgame, lock in crit damage and any lightning penetration or shred.
Playstyle and micro decisions Stand in the middle of fights and let auto-aim handle targeting. Use defensive cooldowns proactively during boss phases. This build excels at sustained single-target damage and is forgiving when you misposition.
Endgame tuning Aim for relics that increase spark chain length or add secondary effects on hit (stun, slow). A relic that grants a small heal on hit to you or your minions increases survivability without sacrificing damage.
Build 4 — Plague Repeater: hybrid single-target and AoE
Overview and why it works Plague Repeater blends single-target punch with AoE cleanup. It’s one of the best choices for boss windows because it can deliver concentrated bursts while still clearing trash efficiently.
Core relic combos A repeater weapon with fire or plague conversion, a relic that triggers on-kill plague explosions, and a molten relic that adds secondary fire explosions are the backbone. On-kill effects multiply clear speed and boss pressure.
Blessing path Start with fire damage and on-kill effects. Mid-game, add projectile count and crit damage. Endgame, lock in on-kill multipliers and any projectile spread that increases coverage.
Playstyle and micro decisions Burst to apply plague and then kite while explosions finish enemies. For bosses, time bursts to coincide with vulnerability windows. The build rewards precise timing and cooldown management.
Endgame tuning Craft a repeater relic that increases on-kill explosion radius and damage. If you can add a relic that converts a portion of hits into guaranteed plague procs, your single-target DPS will skyrocket.
Build 5 — Veil of Quills Minion: swarm control and safety
Overview and why it works Minion builds scale differently: they rely on quantity and minion-specific multipliers. Veil of Quills adds AoE and crowd control to minion swarms, making them viable at Tier 16 when properly supported.
Core relic combos Minion damage and minion count relics are essential. Add a relic that grants minion lifesteal or on-hit healing to keep the swarm alive. A Veil of Quills relic that adds AoE procs from minions increases clear speed.
Blessing path Prioritize minion damage and minion count early. Mid-game, add minion lifesteal and minion crit. Endgame, lock in minion multipliers and any relics that grant minion resistances.
Playstyle and micro decisions Positioning and minion placement matter more than aim. Let minions tank while you buff and debuff. Use your cooldowns to protect minions during boss mechanics.
Endgame tuning Aim for a relic that increases minion attack speed or grants them a chance to trigger plague or fire on hit. Minion lifesteal combined with minion count is the most reliable path to solo Tier 16.
Compact comparison table
| Build | Clear Speed | Bossing | Survivability | Scaling Complexity |
|---|---|---|---|---|
| Plague Split Shot | High | Good | High | Low |
| Ignite Matadeira | Very High | Very High | Medium | Medium |
| Tupã’s Wrath Spark | Medium | High | Very High | Low |
| Plague Repeater | High | Very High | Medium | Medium |
| Veil of Quills Minion | Medium | Good | High | Medium |
Relic crafting philosophy and practical targets
Relic crafting is the single biggest lever for Tier 16 success. The difference between a run that stalls and one that rockets forward is often a single well-rolled relic. Focus on multiplicative stats and synergies rather than flat increases.
Choose one damage axis and stack it. If you pick fire, every relic and blessing that touches your build should increase fire damage, ignite stacks, or fire penetration. If you pick plague, prioritize plague damage, plague spread, and on-kill plague explosions. For minion builds, minion damage and count are king.
Practical relic targets to craft first:
Weapon with +projectile count and elemental damage aligned to your axis.
One relic that converts a portion of your base damage into your chosen element.
One relic that adds on-kill effects (plague clouds, explosions).
Defensive relic that increases conviction pool or grants passive mitigation.
When crafting, aim for these thresholds as a rule of thumb: weapon projectile count +2 or higher, elemental multiplier +30% or more on a core relic, and at least one on-kill or conversion relic in your core set.
Blessing routing and progression strategy
Blessings are the fastest way to pivot a build mid-run. Early runs should favor flat damage and projectile blessings to accelerate clear speed. Once you have a stable relic core, pivot to multiplicative blessings: elemental damage multipliers, crit damage, and on-kill multipliers.
A practical blessing route:
Early: Projectile amount, flat elemental damage.
Mid: Elemental multipliers, on-kill effects.
Late: Crit damage, elemental penetration, and any blessing that multiplies your core relic stat.
Blessings that multiply a relic stat are exponentially more valuable than flat increases. If a blessing multiplies your weapon’s projectile count or your main elemental damage, prioritize it even if it looks less flashy.
Map strategy and speedfarming tips
For speedfarming, clear speed beats single-target DPS. Use builds that apply persistent area damage (Plague Split Shot, Plague Repeater) and prioritize movement and cooldowns that let you chain rooms without stopping.
Key habits for speedfarming:
Pre-apply damage-over-time effects before entering dense rooms.
Use movement cooldowns to skip dangerous packs rather than to chase kills.
Keep one defensive cooldown available for surprise elite packs.
Rotate between offensive runs (to craft relics) and defensive runs (to secure blessings).
If you want to maximize relic drops, alternate between map types that favor your build. For example, Matadeira benefits from high-density maps, while Tupã’s Wrath prefers maps with fewer but tougher elites.
Bossing strategy and encounter tuning
Boss fights are about timing and redundancy. Identify the boss’s vulnerability windows and align your highest-damage cooldowns to them. For builds that rely on damage-over-time, start applying stacks early so the boss is already burning when the window opens.
General boss checklist:
Identify elemental resistances and bring a relic that shreds or converts damage if needed.
Time your major cooldowns for the boss’s vulnerability windows.
Keep movement cooldowns for telegraphed mechanics.
Use on-kill relics to shorten fights by generating additional damage sources.
For Matadeira and Repeater, stacking ignite or on-kill explosions shortens boss phases dramatically. For Tupã’s Wrath, maintain uptime and use defensive cooldowns proactively.
Troubleshooting common problems
Low damage at Tier 16: Replace flat relics with multiplicative ones. Swap a flat +X damage relic for a +% elemental damage relic or a projectile count relic.
Frequent deaths: Increase conviction pool or add a relic that grants passive mitigation. Consider switching to Tupã’s Wrath or a minion build until you can craft defensive relics.
Slow clears: Add projectile count or AoE blessings. Consider a Molten or Matadeira relic to increase burst AoE.
Unreliable boss damage: Ensure you have at least one on-kill or conversion relic that affects single-target damage. Time your cooldowns to the boss’s vulnerability windows.
Sample endgame loadouts you can copy
Plague Split Shot endgame: Weapon with +2 projectile count and plague damage; relics that add plague spread and plague multiplier; blessings: projectile amount, plague damage, crit damage.
Ignite Matadeira endgame: Matadeira with AoE and fire damage; Bottle of Oil relic; fire-orb relic that shreds resistances; blessings: ignite damage, fire damage, AoE.
Tupã’s Wrath endgame: Lightning weapon with chain length relic; lightning-orb relic; conviction pool relic; blessings: lightning damage, physical damage, conviction.
Plague Repeater endgame: Repeater with fire/plague conversion; molten relic for explosions; on-kill plague relic; blessings: fire damage, on-kill effects, projectile count.
Veil of Quills Minion endgame: Minion count weapon; minion damage relic; minion lifesteal relic; Veil of Quills relic; blessings: minion damage, minion count, minion lifesteal.
Small stat snapshot table for tuning decisions
| Stat | Why it matters | Target range |
|---|---|---|
| Projectile Count | Multiplies coverage and clear speed | +2 to +4 |
| Elemental Multiplier | Scales core damage axis | +25% to +60% |
| On-kill Radius | Increases AoE from kills | Small to Medium |
| Conviction Pool | Improves survivability | +10% to +30% |
| Minion Count | Multiplies minion builds | +1 to +3 |
Frequently Asked Questions
Which build is best for a new player Plague Split Shot. It’s forgiving, scales quickly, and requires minimal perfect relics to be effective.
Can I solo Tier 16 with a minion build Yes. Prioritize minion damage, count, and lifesteal relics. Positioning and relic synergy are crucial.
How do I transition a campaign build to Tier 16 Identify the build’s primary damage axis and replace flat relics with multiplicative ones. Craft a weapon with projectile count or elemental damage aligned to your axis, then add one conversion relic and one on-kill relic.
Is there a single best build for all content No. Speedfarming and bossing favor different builds. Ignite Matadeira excels at AoE and boss windows, while Plague Split Shot and Plague Repeater are better for speed.
What relic should I craft first A weapon with projectile count and elemental damage aligned to your chosen axis. It unlocks the fastest scaling path.
Closing recommendations and next steps
Pick one build and commit to crafting three core relics that define it. This focused approach is faster than chasing perfect rolls across many relics. Use the sample endgame loadouts above as templates and adapt relics to your blessed gear. If you want, I can convert any single build into a step-by-step relic craft plan and blessing route tailored to your current gear and relic pool.
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